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KCa3.1 activator testing with 250 nM of free Ca2+ and 1 mM ATP in the internal solution. (A) Raw current traces and plot of current slope (measured between −85 and −65 mV) versus time for KCa3.1 activation by SKA-31 (50, 100, and 250 nM). (B) Effect of riluzole (1, 2, 5, and 10 μM). (C) Effect of EBIO (10, 25, 75, and 100 μM).
