Table 2.
Alternative Splicing Significantly Dysregulated in All Three Evaluated Brain Regions after Prenatal Valproic Acid Treatment
| Anterior Amygdala | Cerebellar Vermis | Orbitofrontal Cortex | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Transcript Cluster ID |
Reference Sequence |
Gene Symbol |
Gene Product | F | p | F | p | F | p |
| 7213582 | NM_012804 | Abcd3 | ATP-binding cassette sub-family D member 3 | 3.481 | 6.93E-08* | 1.532 | 4.73E-02 | 2.574 | 5.54E-05 |
| 7082684 | NM_016987 | Acly | ATP-citrate synthase | 1.914 | 4.95E-03 | 1.721 | 1.61E-02 | 1.657 | 2.35E-02 |
| 7123967 | NM_012493 | Afp | alpha-fetoprotein | 1.973 | 1.61E-02 | 3.672 | 7.32E-06 | 1.983 | 1.54E-02 |
| 7337058 | NM_012903 | Anp32a | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 4.110 | 7.62E-03 | 5.783 | 1.06E-03 | 4.233 | 6.55E-03 |
| 7377029 | NM_001024367 | Armcx1 | Armadillo repeat-containing X-linked protein 1 | 3.937 | 2.46E-03 | 2.45 | 3.62E-02 | 4.330 | 1.23E-03 |
| 7349069 | NM_012913 | Atp1b3 | ATPase, Na+ | 5.745 | 4.01E-02 | 10.564 | 9.99E-03 | 5.188 | 4.88E-02 |
| 7268482 | NM_012508 | Atp2b2 | Plasma membrane calcium-transporting ATPase 2 | 4.219 | 1.75E-08* | 2.605 | 2.42E-04 | 2.217 | 2.14E-03 |
| 7378504 | NM_133288 | Atp2b3 | Plasma membrane calcium-transporting ATPase 3 | 2.751 | 4.02E-05 | 2.628 | 8.95E-05 | 3.634 | 1.12E-07* |
| 7385140 | NM_031785 | Atp6ap1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 2.437 | 9.86E-03 | 3.778 | 1.56E-04 | 3.458 | 4.21E-04 |
| 7384924 | NM_001004224 | Bcap31 | B-cell receptor-associated protein 31 | 2.272 | 3.15E-02 | 2.597 | 1.49E-02 | 2.138 | 4.29E-02 |
| 7137201 | NM_012827 | Bmp4 | bone morphogenetic protein 4 | 2.235 | 4.28E-02 | 2.307 | 3.69E-02 | 2.722 | 1.57E-02 |
| 7335781 | NM_001012201 | Cadm1 | cell adhesion molecule 1 | 3.122 | 7.81E-04 | 3.65 | 1.32E-04 | 5.360 | 4.69E-07* |
| 7092876 | NM_019195 | Cd47 | Cd47 molecule | 2.314 | 2.27E-02 | 3.021 | 3.69E-03 | 2.480 | 1.49E-02 |
| 7215277 | NM_201419 | Clca4 | chloride channel accessory 4 | 8.108 | 9.65E-16* | 2.093 | 6.89E-03 | 2.371 | 1.82E-03 |
| 7065253 | NM_133381 | Crebbp | CREB binding protein | 2.778 | 5.13E-07* | 1.909 | 1.48E-03 | 1.991 | 7.44E-04 |
| 7083616 | NM_001007613 | Ddx5 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 2.503 | 3.28E-02 | 2.000 | 3.09E-02 | 1.892 | 4.30E-02 |
| 7089864 | NM_001012472 | Dgcr14 | DiGeorge syndrome critical region protein 14 | 2.849 | 4.00E-03 | 2.047 | 3.73E-02 | 2.067 | 3.53E-02 |
| 7198615 | NM_013057 | F3 | Tissue factor Precursor | 5.375 | 3.39E-06* | 3.932 | 1.84E-04 | 3.595 | 4.78E-04 |
| 7340407 | NM_021660 | Ip6k2 | Inositol hexakisphosphate kinase 2 | 9.178 | 9.05E-08* | 3.964 | 1.20E-03 | 4.646 | 3.05E-04 |
| 7231634 | NM_031045 | Itpka | inositol 1,4,5-trisphosphate 3-kinase A | 2.185 | 2.56E-02 | 2.495 | 1.09E-02 | 2.672 | 6.61E-03 |
| 7326239 | NM_212523 | Kif5a | kinesin family member 5A | 1.850 | 6.62E-03 | 1.634 | 2.49E-02 | 1.639 | 2.42E-02 |
| 7070380 | NM_001012011 | Lig3 | DNA ligase | 2.548 | 4.40E-04 | 1.891 | 1.35E-02 | 2.154 | 3.59E-03 |
| 7333434 | NM_001025054 | LOC500956 | hypothetical protein LOC500956 | 2.512 | 1.04E-02 | 4.395 | 5.00E-05 | 5.167 | 5.96E-06* |
| 7322009 | NM_021859 | Matk | Megakaryocyte-associated tyrosine-protein kinase | 4.746 | 1.47E-06* | 2.455 | 5.55E-03 | 2.407 | 6.57E-03 |
| 7059820 | NM_001015013 | Mtvr2 | mammary tumor virus receptor 2 | 3.766 | 4.30E-02 | 5.004 | 1.87E-02 | 4.918 | 1.98E-02 |
| 7322533 | NM_020087 | Notch3 | Notch homolog 3 (Drosophila) | 1.647 | 1.02E-02 | 1.474 | 3.65E-02 | 1.433 | 4.83E-02 |
| 7233312 | NM_012746 | Pcsk2 | Neuroendocrine convertase 2 Precursor | 2.616 | 4.23E-03 | 2.02 | 2.90E-02 | 2.379 | 9.22E-03 |
| 7289582 | NM_199253 | Pcsk9 | proprotein convertase subtilisin | 1.742 | 4.50E-02 | 2.085 | 1.19E-02 | 1.756 | 4.28E-02 |
| 7320471 | NM_031715 | Pfkm | 6-phosphofructokinase | 2.652 | 1.85E-04 | 2.008 | 6.53E-03 | 2.029 | 5.85E-03 |
| 7179966 | NM_017175 | Pkn1 | Serine/threonine-protein kinase N1 | 4.128 | 3.01E-08* | 3.43 | 1.92E-06* | 3.129 | 1.14E-05 |
| 7329136 | NM_001164298 | Plec | plectin | 1.454 | 1.61E-02 | 1.504 | 9.55E-03 | 1.565 | 4.99E-03 |
| 7339147 | NM_057194 | Plscr1 | phospholipid scramblase 1 | 2.510 | 1.82E-02 | 2.148 | 4.19E-02 | 2.956 | 6.46E-03 |
| 7139367 | NM_053999 | Ppp2r2a | protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha | 2.092 | 9.72E-03 | 3.057 | 1.28E-04 | 2.888 | 2.79E-04 |
| 7219948 | NM_031324 | Prep | Prolyl endopeptidase | 5.697 | 6.12E-09* | 4.335 | 1.46E-06* | 5.013 | 9.27E-08* |
| 7300035 | NM_019163 | Psen1 | Presenilin-1 | 5.727 | 4.40E-07* | 7.000 | 1.20E-08* | 4.297 | 3.15E-05 |
| 7302329 | NM_031600 | Ptprn2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 1.845 | 9.58E-03 | 1.782 | 1.38E-02 | 2.220 | 9.66E-04 |
| 7042063 | NM_001004261 | Pyroxd2 | Pyridine nucleotide-disulfide oxidoreductase domain 2 | 3.345 | 5.41E-05 | 2.558 | 1.66E-03 | 4.071 | 2.22E-06* |
| 7119529 | NM_022390 | Qdpr | quinoid dihydropteridine reductase | 3.468 | 5.68E-03 | 4.999 | 3.89E-04 | 5.954 | 7.97E-05 |
| 7174465 | NM_017315 | Slc23a1 | solute carrier family 23 (nucleobase transporters), member 1 | 2.071 | 1.49E-02 | 2.049 | 1.61E-02 | 2.348 | 5.07E-03 |
| 7138066 | NM_053442 | Slc7a8 | solute carrier family 7 (cationic amino acid transporter, y+ sys | 2.471 | 6.82E-03 | 1.927 | 3.87E-02 | 2.626 | 4.09E-03 |
| 7365728 | NM_173338 | Slco6c1 | solute carrier organic anion transporter family, member 6c1 | 2.108 | 1.84E-02 | 1.828 | 4.64E-02 | 2.984 | 8.41E-04 |
| 7348411 | NM_031728 | Snap91 | Clathrin coat assembly protein AP180 | 1.983 | 3.18E-03 | 2.041 | 2.18E-03 | 2.249 | 5.42E-04 |
| 7045017 | NM_175583 | Taar4 | Trace amine-associated receptor 4 | 3.576 | 4.68E-03 | 3.161 | 9.91E-03 | 5.199 | 2.77E-04 |
| 7320452 | NM_001008358 | Tmem106c | transmembrane protein 106C | 2.468 | 2.65E-02 | 2.719 | 1.57E-02 | 2.952 | 9.69E-03 |
| 7303979 | NM_001014195 | Tmem214 | transmembrane protein 214 | 2.277 | 8.30E-03 | 2.045 | 1.93E-02 | 2.778 | 1.26E-03 |
| 7219299 | NM_001013033 | Tspyl1 | TSPY-like 1 | 21.453 | 1.23E-03 | 5.538 | 4.31E-02 | 16.525 | 2.82E-03 |
| 7378941 | NM_001013933 | Ube2a | ubiquitin-conjugating enzyme E2A | 3.788 | 3.21E-03 | 3.404 | 6.38E-03 | 5.201 | 2.76E-04 |
| 7084520 | NM_138844 | Unc13d | Protein unc-13 homolog D | 1.841 | 4.03E-03 | 1.69 | 1.18E-02 | 1.884 | 2.91E-03 |
| 7154203 | NM_001001516 | Usp19 | ubiquitin specific peptidase 19 | 1.737 | 1.34E-02 | 1.985 | 2.73E-03 | 1.858 | 6.25E-03 |
| 7331440 | NM_017058 | Vdr | Vitamin D3 receptor | 3.091 | 4.71E-03 | 3.426 | 2.16E-03 | 3.630 | 1.34E-03 |
| 7295338 | NM_017154 | Xdh | xanthine dehydrogenase | 1.495 | 4.03E-02 | 2.690 | 2.96E-06* | 2.267 | 1.17E-04 |
*
Genes that surpassed Bonferroni corrected significance for that brain region.
Genes that may be relevant to social interaction behavior are indicated in bold.