. Author manuscript; available in PMC: 2014 Jun 1.

Published in final edited form as: Nat Immunol. 2013 Oct 27;14(12):1256–1265. doi: 10.1038/ni.2746

Table 1.

Genes upregulated by gp120-α₄β₇ interaction
Biological process	Genes present
Regulation of apoptosis	ABR, ACVR1, ADA, BARD1, BCL6, BIRC2, C14ORF153, CASP8AP2, CCL2, CD27, CD38, CDKN1A (p21), CDKN2A, DYRK2, FURIN, ID3, IDO1, IER3, IL1A, IL1B, IL2RA, INHBA, JUN, KLF10, KRAS, MYO18A, NOTCH1, PPP1R13B, PRKCI, PTGS2, RRM2B, RXRA, SEMA4D, SERPINB2, SMAD6, SMAD7, SPHK1, STK17A, TGFB1, TNF, TNFAIP8, TNFRSF9
Chemotaxis	CCL2, CCL20, CCL4L1, CCR6, CCRL2, CXCL16, ENG, IL1B, IL8, NRP2, PLAUR
Immune/Inflammatory response	ACVR1, CCL2, CCL20, CCL4L1, FCRL4, IDO1, IL1A, IL1B, IL1RN, IL2RA, IRAK2, TNFAIP6, KDM6B, RGS1, RXRA, TGFB1, TLR1, TNF
Defense response	ACVR1, ANKRD1, CCL2, CCL20, CCL4L1, CCR6, CD83, CXCL16, HIST1H2BE, IDO1, IL1A, IL1B, IL1RN, IL2RA, INHBA, IRAK2, KDM6B, LSP1, RXRA, TGFB1, TLR1, TNF
Positive regulation of lymphocyte proliferation	ADA, BCL6, BLM, CDKN1A (p21), CD38, IL1B, IL2RA, RGS1

Genes down-modulated by gp120-α₄β₇ interaction
Biological process	Genes present
Immune response	BMP6, BTLA, CBLB, CD86, CR1, HLA-DOB, IGKC, IGKV1-5, IGKV4-1, LILRB1, LY9, NCR3, OAS1, SKAP1
Inflammatory response	ALOX5, BMP6, CR1, CYSLTR1, NCR3, PLA2G7
Defense response	ALOX5, BMP6, CR1, CYSLTR1, FGR, HCK, NCR3, PLA2G7, RNASE6
Positive regulation of immune system process	CBLB, CD86, CR1, NCK2, SH2B2, FCER2, NCR3, SKAP1