. Author manuscript; available in PMC: 2014 Jun 1.

Published in final edited form as: Nat Immunol. 2013 Oct 27;14(12):1256–1265. doi: 10.1038/ni.2746

Table 2.

Genes upregulated by gp120--α₄β₇ interaction
Biological process	Genes present
Leukocyte activation and differentiation	ADA, BCL3, CD79A, CSF2, CXCR4, ELF4, IL10, LCP2, MYH9, TGFB1, TLR1, TLR6
Regulation of apoptosis	ABR, ADA, BCL3, BTG2, CDKN1 (P21), CSF2, CTSB, FOXL2, FURIN, ID3, IL10, IL2RB, IL6R, INPP5D, KLF10, PTGS2, RUNX3, SMAD7, SPHK1, TGFB1, TNFRSF9
Leukocyte proliferation	CD79A, CXCR4, ELF4, IL10, TGFB1
Regulation of lymphocyte proliferation	ADA, CDKN1A (P21), FCRL4, IL10, INPP5D, TGFB1, TNFRSF14
Immune system development	ADA, BCL3, CD79A, CSF2, DNASE2, ID2, IL10, MYH9, TGFB1, TIPARP, TTC7A

Genes down-modulated by gp120--α₄β₇ interaction
Biological process	Genes present
Immune response	BNIP3, CD86, ENPP2, GBP1, IFI44L, IFI6, LILRB1, LOC652493, LY9, NCF2, OAS1, OAS3, PTPRC, TRIM22
Cell proliferation	CD86, IL15RA, LAMP3, PTPRC, STAT4, TCF7L2