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Clustered RAN-positive cells in hippocampus and motor cortex and RAN aggregates in motor neurons. IHC showing cytoplasmic α-GPS/AS aggregates in: (A) layer III of motor cortex; (B) upper motor neuron in layer V of the motor cortex; (C) lower motor neurons in the lumbar spinal cord (LSC); (D) in CA and (E) DG regions of the hippocampus. (F and G) Abundant PA-CTAS and PR-CTAS cytoplasmic inclusions in the presubiculum (PrSub) from one patient.
