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. 2013 Dec 2;110(51):20575–20580. doi: 10.1073/pnas.1320454110

Fig. 5.

Fig. 5.

Dexras1 knockout mice are resistant to HFD-induced obesity. (A) Body weight gain of WT and Dexras1 KO mice on normal diet (ND) or HFD (n = 10 per group). (B) Dexras1 KO mice are resistant to diet-induced weight gain. (C) Body composition (% body weight) analysis of WT and KO mice on normal diet (n = 7 per group) or HFD for 11 wk (n = 7 per group). (D) Weight of various tissues from WT and KO mice on normal diet (n = 4 per group) (Left). Weight of epididymal WAT from WT and KO mice fed a HFD (n = 6 per group) (Right). (E) Decreased adipose tissue mass in knockouts on normal diet or HFD. (F) H&E staining of epididymal WAT from wild-type or Dexras1 KO mice on normal diet or HFD for 10 wk. (Scale bar: 100 μm.) (G) Distribution of adipocyte size in epididymal WAT from wild-type or Dexras1 KO mice on normal diet (n = 3 per group) or HFD (n = 3 per group). Mean diameter: WT on normal diet, 50.31 ± 10.25 μm; KO on normal diet, 48.4 ± 8.81 μm; WT on HFD, 85.44 ± 21.43 μm; and KO on HFD, 67.53 ± 15.79 μm. The diameters of epididymal white adipocyte were determined by ImageJ, and more than 500 adipocytes were examined for each group. All data are means ± SD. *P < 0.05; ***P < 0.001.