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Schematic of Drosophila wing imaginal disk and core Fat pathway components. (A) Morphogens Decapentaplegic (Dpp; yellow) and Wingless (Wg; green) are secreted at anterior-posterior and dorsal-ventral compartment boundaries, respectively, setting up gradients of Fat pathway components like Ds. (B) Protocadherin Ds binds to Fat, which, in active form, inhibits the membrane localization of Dachs (green). Dachs promotes growth by enhancing accumulation of Yorkie (red) in the nucleus.
