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. 2013 Sep 25;39(2):499–506. doi: 10.1038/npp.2013.223

Figure 4.

Figure 4

Restored expression of GLT-1 is required for the PPF-dependent decrease in reinstatement. (a) Experimental design. Vivo-morpholino microinjections were performed on 3 sequential days, and saline or PPF administration began on the third day of vivo-morpholino microinjection. Animals then received chronic treatment with saline or PPF (10 mg/kg, i.p.). (b) Active lever presses during cue-primed reinstatement to cocaine. (#p<0.001). (c), In a separate group of animals, efficacy of antisense to GLT-1 was determined using western blot (n=6 per group). C, control sequence; A, antisense. (d) Placement of microinjections for use in behavioral analysis (b) was determined by Cresyl violet staining. Open circles indicate saline treatment, closed circles indicate PPF treatment. *p<0.05.