Figure 4.

Effects of autoreceptor knockdown on social behavior. In Phase 1 (a), knockdown mice showed decreased locomotion (b), but there was no effect of genotype or rearing condition on time spent in social investigation (c) or preference for a social stimulus (d). In Phase 2 (e), 5-HT1A knockdown mice traveled a shorter distance (f) and displayed lower levels of overall sociability (total time spent investigating either mouse) (g), a phenotype that is exacerbated by exposure to early-life stress. Wild-type animals exposed to early-life stress failed to discriminate between novel and familiar individuals, whereas their knockdown littermates retained this ability (h). n=11–21; *p<0.05, **p<0.01.