Table 3. Canonical Pathways Found by the IPA Software to be Significantly Affected in the Frontal Cortex of Li-Treated WT Mice, IMPA1 KO Mice, and SMIT1 KO Mice.

Canonical pathway	Ratioa IMPA1 KO	P-value IMPA1 KO	Ratio IMPA1_Li	P-value IMPA_Li	Ratio SMIT1 KO	P-value SMIT1 KO	Ratio SMIT_Li	P-value SMIT_Li
Oxidative phosphorylation	17/166	6.77E−06	13/166	2.43E−04	10/166	5.14E−03	19/166	3.86E−06
Mitochondrial dysfunction	14/125	8.17E−05	8/125	2.25E−02	12/125	1.26E−04	17/125	3.89E−06
Ubiquinone biosynthesis	10/119	2.33E−04	8/119	1.48E−03	7/119	1.41E−02	9/119	2.12E−03

^aRatio indicates the number of genes from the data set that map to the pathway divided by the total number of genes that map to the canonical pathway.

Gene expression data of the IMPA1 KO mice and Li-treated WT mice from the IMPA1 colony (IMPA1_Li), SMIT1 KO mice and Li-treated WT mice from the SMIT1 colony (SMIT_Li) were subjected to the IPA canonical pathway analysis. Genes from the uploaded data sets that met the cutoffs (P<0.05, f.c.>1.1 and P<0.035, f.c.>1.15 for the IMPA1 and the SMIT1 colonies, respectively, as justified under Materials and methods) and that were associated with a canonical pathway in the Ingenuity Knowledge Base were considered for the analysis. Fisher's exact test was used to calculate the P-value determining the probability that the association between the genes in the data set and the canonical pathway is explained by chance only.