Table 4. Genes with Common Expression Change in IMPA1 KO, SMIT1 KO, and Li-Treated Mice.

Gene symbol	Entrez gene name	Fold of change SMIT KO	P-value SMIT KO	Fold of change SMIT_Li	P-value SMIT_Li	Fold of change IMPA KO	P-value IMPA KO	Fold of change IMPA_Li	P-value IMPA_Li
Cox5aa	Cytochrome C oxidase, subunit Va	1.27	0.004	1.22	0.007	1.16	0.02	1.18	0.016
Gaa	Glucosidase, alpha, acid	−1.32	0.03	−1.4	0.01	−1.2	0.015	−1.16	0.036
Gemin4	gem (nuclear organelle) associated protein 4	−1.18	0.016	−1.25	0.003	−1.12	0.013	−1.15	0.006
Ndufab1a	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex,	1.16	0.019	1.2	0.005	1.2	0.01	1.14	0.03
Ndufs7a	NADH dehydrogenase (ubiquinone) Fe-S protein 7	1.2	0.042	1.22	0.02	1.15	0.014	1.13	0.02
Rc3h1	RING CCCH (C3H) domains 1	−1.11	0.02	−1.22	0.0005	−1.08	0.04	−1.1	0.02
Uqcrfs1	Ubiquinol-cytochrome C reductase, Rieske iron-sulfur polypeptide 1	1.15	0.03	1.3	0.0008	1.2	0.009	1.14	0.04

^aGenes previously reported to be upregulated by lithium treatment or downregulated in/genetically associated with bipolar disorder in at least two independent studies. All of them are related to mitochondrial function.The designations SMIT_Li and IMPA_Li as in Table 3.