Figure 1.

Induction of human immunodeficiency virus 1 (HIV-1) Tat potentiated the duration of cocaine-induced locomotor activity. C57BL/6J (circles) or GT-tg bigenic (squares) mice were pretreated for 7 days with vehicle (saline 0.9%, i.p.; depicted as open icons) or Dox (100 mg/kg, i.p.; depicted as filled icons) and administered saline (0.9%, s.c.) or cocaine (10 mg/kg, s.c.) before locomotor assessment in an open field for 30 min. Cocaine significantly increased the distance (cm) traveled in the open field amongst all groups compared with saline, but this potentiation was greater among Tat-induced GT-tg mice than other groups following the initial 10 min in the task. *Indicates significant difference from uninduced GT-tg bigenic mice, p<0.05, repeated measures analysis of variance (ANOVA).