Table 2. Connectivity and HAMD17 Values for Each Subject.

(A)
DMPFC Seed
HAMD change	Time 1 insula	Time 2 insula	Time 1 thalamus	Time 2 thalamus	Time 1 MCC	Time 2 MCC	Time 1 caudate	Time 2 caudate
24	0.53	−2.43	−8.44	−0.93	5.5	3.36	3.58	1.52
20	−1.27	3.31	−0.57	−2.36	−4.49	6.25	−1.54	4.46
18	−0.78	−4.38	−1.17	−4.77	3.42	2.34	−1.76	2.27
16	3.06	2.42	−8.86	−6.69	5.34	8.82	−3.49	−3.55
15	3.01	−4.68	−4.49	0.3	9.49	4.94	1.17	−0.5
14	0.29	−3.81	−4.74	−3.64	5.15	3.31	1.65	2.18
14	−0.64	−1.87	−6.72	−0.58	4.88	5.26	6.57	3.69
10	−3.06	2.46	−7.3	1.08	3.32	3.48	4.97	6.8
10	4.71	3.38	−4.74	−7.76	3.33	11.37	6.98	1.31
10	3.75	0.16	−3.76	−3.83	3.81	2.12	0.67	−1.16
10	4.04	2.26	−8.22	−0.82	10.55	2.32	−5.72	0.53
10	1.42	2.63	0.75	−0.71	5.36	10.02	6.26	1.19
10	−2.32	−7.93	−2.71	−3.64	6.56	0.62	2.76	−1.11
9	4.25	−1.06	−0.77	4.26	4.41	0.89	5.89	3.38
8	1.99	0.82	−1.34	1.68	2.7	5.33	−0.3	0.43
7	2.55	1.67	−1.27	−4.08	2.56	11.71	1.14	10.03
7	−5.89	−2.66	1.38	1.66	−1.35	6.93	2	7.59
5	−1.6	−1.16	−1.39	0.16	4.52	3.33	5.46	0.34
3	−6.47	−0.52	−1.65	−1.92	1.38	4.51	−0.57	6.65
2	3.67	0.62	−2.92	−1.27	8.18	5.47	8.26	2.93
2	−2.89	2.15	−6.91	−2.95	10.23	8.83	5.75	−0.91
1	2.77	5.44	4	−1.57	6.06	6.52	4.89	0.33
−1	−3.27	−0.77	2.38	1.13	3.7	5.21	−0.02	1.72
−2	−1.47	4.52	2.5	−1.4	4.39	8.23	2.67	5.57
Correlation with HAMD change	0.21	−0.35	−0.53	−0.22	−0.16	−0.22	−0.26	−0.17
Average ⩾10	0.98	−0.65	−4.69	−2.64	4.79	4.94	1.7	1.36
Average <10	−0.58	0.82	−0.54	−0.39	4.25	6.09	3.2	3.46
(B)
sgACC seed
HAMD change	Time 1 MCC	Time 2 MCC	Time 1 caudate	Time 2 caudate	Time 1 insula	Time 2 insula	Time 1 thalamus	Time 2 thalamus
24	−0.92	−3.6	−3.36	2.94	−1.39	−3.37	−9.69	−0.07
20	−3.30	−0.04	2.81	−0.86	1.36	3.12	−2.46	−0.12
18	1.69	1.19	−0.84	0.56	0.19	0.36	0.57	−1.13
16	−1.57	−3.13	−1.31	4.84	−2.4	−0.58	0.94	0.84
15	2.42	−3.3	−3.86	3.17	−3.29	0.98	−1.19	−0.57
14	−2.41	−2.73	−0.18	−1.1	−1.1	−1.32	1.86	2.05
14	4.06	−5.05	−6.1	7.81	1.85	−2.88	−4.72	−3.06
10	−1.45	−0.59	2.36	−1.94	3.92	−2.64	−4.96	−0.71
10	−0.65	−10.04	−6.86	8.86	3.62	−3.12	−2.59	7.94
10	0.1	−7.16	−4.32	−0.6	−0.86	−7.61	0.68	−0.34
10	1.93	3.08	0.28	2.84	5.09	3.21	−0.47	3.55
10	0.91	2	0.31	2	0.4	2.04	−4.87	−2.65
10	3.76	−0.59	−2.59	1.41	2.99	5.67	−2.07	3.62
9	−1.25	2.25	2.45	0.83	−3.37	0.09	0.52	0.55
8	3.02	−1.73	−3.28	5.99	3.42	4.21	3.49	−2.34
7	2.52	4.73	1.81	2.62	2.36	6.82	−2.81	−0.93
7	5.27	2.92	−1.63	9.05	2.88	−1.68	2.05	−1.43
5	−0.8	2.54	2.56	−7.21	−2.38	−0.17	−3.08	−0.02
3	1.85	4.94	3.05	2.11	0.49	7.46	−2.18	2.85
2	4.35	−0.48	−1.29	3.46	3.91	4.27	−1.01	0.66
2	−1.26	−3.7	−0.39	2.19	4	0.88	3.02	0.36
1	0.72	2.25	2.12	−0.25	3.31	1.03	0.44	−1.69
−1	−3.02	3.67	7.25	4.35	−0.86	5.33	2.31	−0.69
−2	−0.31	8.78	8.68	0.35	3.28	4.91	−0.88	−2.85
Correlation with HAMD change	−0.12	−0.48	−0.52	0.05	−0.37	−0.44	−0.43	0.08
Average ⩾10	0.35	−2.3	−1.82	2.3	0.8	−0.47	−2.23	0.72
Average <10	1.01	2.38	1.94	2.14	1.55	3.01	0.17	−0.5

Abbreviations: DMPFC, dorsomedial prefrontal cortex; HAMD, Hamilton Depression Rating Scale; MCC, midcingulate; sgACC, subgenual cingulate cortex.

Connectivity values for the dmPFC (A) and sgACC (B) seeds (extracted z-scores for each target region). Subjects are ranked by HAMD₁₇ change scores. At bottom are correlations between connectivity and HAMD₁₇ change scores for each time point. In addition, the mean connectivity value for subjects above (⩾10) and below (<10) the median HAMD₁₇ change score is provided.