Figure 2.

(Top) Steady-state concentrations in a system with N = 2 ceRNAs, obtained by fixing all parameters but the transcription rate b₁ of ceRNA 1. (Bottom) Fractions of free molecules, namely ${\varphi }_1=\left[m_1\right]/\left(\left[m_1\right]+\left[c_1\right]\right)$, ${\varphi }_2=\left[m_2\right]/\left(\left[m_2\right]+\left[c_2\right]\right)$, and ${\varphi }_{\mu }=\left[\mu \right]/\left(\left[\mu \right]+\left[c_1\right]+\left[c_2\right]\right)$, versus b₁. The dynamical range of the cross-talk interaction between the two ceRNAs corresponds to the window where free and bound molecules have similar concentration, i.e., to the $\mathcal{S}$-regime. Parameters for this case (in their respective units) are as follows: b₂ = 10, $d_1=d_2=\delta =1$, $k_1^{+}={10}^3$, $k_2^{+}=1$, $k_1^{-}=k_2^{-}={10}^{-3}$, σ₁ = σ₂ = 10, and κ₁ = κ₂ = 1.