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. 2013 Mar 5;104(5):986–996. doi: 10.1016/j.bpj.2013.01.028

Figure 1.

Figure 1

(a) Traditional PEA of chondrocyte RCJ-P cells, which uses fixed RBCs to visualize the extent of the PCM. Measurement of chondrocytes at the center of the flat, elongated side of the cell yields an average PCM thickness of L0,PEA = 7.0 ± 0.5 μm (n = 110 cells). In vivo, there is an ambiguous transition between the surface-bound PCM and the ECM, with the ECM being partially intertwined with the PCM. In the in vitro assays, there is no significant ECM component. (b) Schematic of the PCM. HA polymer chains decorated with PGs (e.g., aggrecan) are bound to surface receptors.