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Dual receptors lead to dual functions of SDF-1 (CXCL12) in glioblastoma vasculogenesis after radiation therapy. Irradiated tumor cells secrete SDF-1, which binds CXCR4 expressed by marrow-derived myelomonocytes and CXCR7 expressed by marrow-derived endothelial precursors, which together participate in vasculogenesis.
