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WB-based brachyury and signal transduction. (A) Like the corresponding human tumor samples (h), the xenografts derived from patients 2, 3, 4 and 5 expressed brachyury throughout all of the transplantation steps (P). (B and C) In the xenograft samples, the MAP cascade (ERK1-2) and 4E-BP1 were more activated than AKT or S6. C+: positive controls.
