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. Author manuscript; available in PMC: 2013 Dec 24.
Published in final edited form as: Curr HIV Res. 2012 Apr;10(3):218–227. doi: 10.2174/157016212800618093

Figure 2. Highly focal productive infection in an endocervix 4 days after intravaginal simian immunodeficiency virus (SIV) inoculation.

Figure 2

A. Montage of images (magnification, ×100) of a single section of endocervix, among 20 sections examined from monkey 31385, in which one focus (encircled) of SIV RNA-positive cells was detectable. B. SIV RNA-positive cells at a higher magnification. The double-headed arrow points to two SIV RNA-positive cells that appear to be intraepithelial lymphocytes. The single-headed arrow points to a focal collection of SIV RNA-positive cells in the endocervical mucosa. SIV RNA was detected by in situ hybridization (ISH) with radiolabeled riboprobes. In the developed radioautographs viewed with transmitted light, the SIV RNA-positive cells appear black because of the large number of silver grains overlying the cell. Original magnification, ×100. Reproduced from: Miller CJ, et. al. Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus. J Virol 2005;79(14):9217–9227, with permission.