Figure 5.

Responses to current injection and NMDAR activation in an electrically coupled population of 30 single-compartment model dINs. A, Injection of depolarizing current into one dIN leads to a single spike and spread of current to depolarize nearby neurons. B, If negative current is injected during the same depolarization shown in A (to imitate reciprocal inhibitory IPSPs), the dIN fires a single spike on rebound (Soffe et al., 2009). C, Maintained activation of sufficient NMDARs in all dINs leads to depolarization and rhythmic pacemaker-like firing like that in dINs perfused with NMDA (Li et al., 2010). The paler traces show responses in 9 neighboring coupled neurons which are displaced vertically so they can be seen.