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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1986 Dec;83(23):9159–9163. doi: 10.1073/pnas.83.23.9159

Theory of an immune system retrovirus.

L N Cooper
PMCID: PMC387094  PMID: 2947242

Abstract

Human immunodeficiency virus (HIV; formerly known as human T-cell lymphotropic virus type III/lymphadenopathy-associated virus, HTLV-III/LAV), the retrovirus that infects T4-positive (helper) T cells of the immune system, has been implicated as the agent responsible for the acquired immune deficiency syndrome. In this paper, I contrast the growth of a "normal" virus with what I call an immune system retrovirus: a retrovirus that attacks the T4-positive T cells of the immune system. I show that remarkable interactions with other infections as well as strong virus concentration dependence are general properties of immune system retroviruses. Some of the consequences of these ideas are compared with observations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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