Table 3.
Genes involved in detoxification having an eQTL
| Name | eQTL | |||||
|---|---|---|---|---|---|---|
|
Standard |
Systematic |
Localization
a
|
Lod score |
Regulation
b
|
Venn group |
SGD Function |
|
Ions Detoxification |
|
|
|
|
|
|
|
MNR2 |
YKL064W |
chr2:151 |
4,49 |
unknown |
23 |
Putative magnesium transporter; has similarity to Alr1p and Alr2p which mediate influx of Mg2+ and other divalent cations |
|
ALR2 |
YFL050C |
chr6:30 |
5,88 |
Self |
123 |
Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition |
|
SSU1 |
YPL092W |
chr16:371 |
5,92 |
Self |
123 |
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein |
|
Drug Transport |
|
|
|
|
|
|
|
TPO2 |
YGR138C |
chr7:761 |
17,28 |
Self |
123 |
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily |
|
SNG1 |
YGR197C |
chr15:639 |
5,24 |
YRR1 |
1 |
Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance |
|
ERC1 |
YHR032W |
chr2:624 |
4,09 |
unknown |
13 |
Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily |
|
PDR11 |
YIL013C |
chr12:659 |
4,78 |
HAP1/PDR8 |
123 |
ATP-binding cassette (ABC) transporter multidrug transporter involved in MDR; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p |
|
QDR2 |
YIL121W |
chr12:680 |
10,31 |
HAP1/PDR8 |
123 |
Multidrug transporter of the major facilitator superfamily required for resistance to quinidine barban cisplatin and bleomycin; may have a role in potassium uptake |
|
GEX2 |
YKR106W |
chr11:658 |
13,66 |
Self |
123 |
Proton:glutathione antiporter localized to the vacuolar and plasma membranes; almost identical to paralog Gex1p; potential role in resistance to oxidative stress |
|
TPO1 |
YLL028W |
chr12:86 |
9,89 |
Self |
123 |
Polyamine transporter that recognizes spermine putrescine and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH |
|
TPO4 |
YOR273C |
chr12:659 |
4,61 |
HAP1/PDR8 |
13 |
Polyamine transport protein recognizes spermine putrescine and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily |
|
PDR12 |
YPL058C |
chr13:116 |
7,50 |
WAR1 |
123 |
Plasma membrane ATP-binding cassette (ABC) transporter weak-acid-inducible multidrug transporter required for weak organic acid resistance; regulated by War1p |
|
Transcription factor |
|
|
|
|
|
|
|
HAP1 |
YLR256W |
chr12:673 |
6,22 |
Self |
123 |
Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen |
|
PDR8 |
YLR266C |
chr16:138 |
5,00 |
unknown |
2 |
Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the PDR phenomenon |
|
WAR1 |
YML076C |
chr12:673 |
6,57 |
HAP1/PDR8 |
123 |
Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34 |
|
YRR1 |
YOR162C |
chr15:639 |
5,03 |
Self |
13 |
Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p acting on an overlapping set of target genes |
|
FZF1 |
YGL254W |
chr7:21 |
4,02 |
Self |
123 |
Transcription factor involved in sulfite metabolism, identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity |
|
Other/Unknown |
|
|
|
|
|
|
|
SVS1 |
YPL163C |
chr16:251 |
9,55 |
Self |
123 |
Cell wall and vacuolar protein required for wild-type resistance to vanadate |
|
YKR104W |
YKR104W |
chr11:651 |
4,63 |
Self |
13 |
Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C |
|
YLR046C |
YLR046C |
chr12:238 |
5,72 |
Self |
123 |
Putative membrane protein transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance |
|
YJL216C |
YJL216C |
chr10:42 |
11,36 |
Self |
123 |
Protein of unknown function similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p along with other genes involved in the PDR phenomenon |
| YLR179C | YLR179C | chr12:689 | 4,08 | HAP1/PDR8 | 23 | Protein of unknown function transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; not essential |
aLocalization of the center of hotspot given in chromosome:kilo base pair.
b“Self” mean the eQTL is closer than 40 kpb to the gene controlled.