Table 4.
Gene expression modified by PDR8 allelic switch
| ORF | Name | eQTL | LogFC | AdjPv | SGD function |
|---|---|---|---|---|---|
|
YIL121W |
QDR2 |
hotspot8 |
2,234 |
<10e-05 |
Multidrug transporter of the major facilitator superfamily required for resistance to quinidine barban cisplatin and bleomycin |
|
YLR179C |
YLR179C |
hotspot8 |
0,897 |
0,0026 |
Protein of unknown function transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance |
|
YLR149C |
YLR149C |
- |
1,349 |
<10e-05 |
Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport |
|
YCR098C |
GIT1 |
- |
0,548 |
0,005 |
Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate |
|
YIL120W |
QDR1 |
- |
0,472 |
0,0046 |
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban |
| YLR266C | PDR8 | chr16:138 | −0,493 | 0,0032 | Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon |