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Reagents and conditions: (a) CH2O, EtOH, R7H, 80 °C 24 h. (b) NaOH, EtOH, 70 °C, 20 min. (c) 1 M Na2CO3, pH 8.
BpMetAP1 IC50 values in μM with standard error obtained from nonlinear regression analysis of the average observed activity (in triplicate) versus inhibitor concentration data.
In cases where analysis is limited by compound solubility, the minimum estimate of IC50 is provided.
