Table 2. Cartilage loss in the tibiofemoral joint stratified by baseline cartilage score in regard to number of associated pathologies.
| Cartilage status in subregion at baseline (tibiofemoral joint – 10 subregions) | |||||||
|---|---|---|---|---|---|---|---|
| Subregions and associated risk factor status | All Grades | Grades 0 and 1 | Grade 2 | Grade 2.5 | Grade 3 | Grade 4 | Grades 5 and 6 |
| Subregions included (%) | 13524 (100.0) | 9747 (72.1) | 476 (3.5) | 173 (1.3) | 1983 (14.7) | 49 (0.3) | 1096 (8.1) |
| Subregions with cartilage loss (%) | 1119 (8.3) | 352 (3.6) | 133 (27.9) | 34 (19.7) | 427 (21.5) | 11 (22.4) | 162 (14.8) |
|
| |||||||
| Subregions with cartilage loss and no associated pathologies(%) | 375 (4.4) | 180 (2.5) | 66 (22.6) | 11 (10.7) | 106 (14.1) | 1 (11.1) | 11 (7.4) |
| aOR1 (Reference) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Subregions with cartilage loss and one associated pathologies2 (%) | 268 (10.9) | 99 (6.1) | 35 (28.9) | 12 (28.6) | 93 (19.7) | 3 (30.0) | 26 (14.1) |
| aOR1 (95% CI) p | 2.53 (2.03-3.15) <.0001* | 2.46 (1.74-3.46) <0.001* | 1.45 (0.89-2.38) 0.13 | 3.60 (1.40-9.32) 0.008* | 1.43 (1.00-2.04) 0.047* | 3.54 (0.25-50.2) 0.34 | 1.95 (0.79-4.83) 0.15 |
| Subregions with cartilage loss and two associated pathologies3 (%) | 338 (18.2) | 70 (8.8) | 31 (53.4) | 9 (40.9) | 167 (27.7) | 3 (13.6) | 58 (16.0) |
| aOR1 (95% CI) p | 4.32 (3.42-5.47) <.0001* | 3.70 (2.51-5.44) <0.001* | 3.62 (1.98-6.63)<0.001* | 4.86 (1.64-14.5) 0.004* | 2.25 (1.58-3.21) <0.001* | 1.47 (0.14-15.8) 0.74 | 2.47 (1.00-6.07) 0.048* |
| Subregions with cartilage loss and three associated pathologies4 (%) | 138 (22.7) | 3 (8.3) | 1 (20.0) | 2 (33.3) | 61 (39.6) | 4 (50.0) | 67 (16.8) |
| aOR1 (95% CI) p | 5.30 (3.95-7.12) <.0001* | 3.59 (1.10-11.7) 0.03* | 1.03(0.09-11.9)0.98 | 4.73(0.74-30.2)0.09 | 3.75 (2.40-5.85) <0.001* | 16.29 (0.89-296) 0.06 | 2.57 (0.97-6.83) 0.06 |
|
| |||||||
| p for trend | <.0001* | <.0001* | 0.0004* | 0.0011* | 0.0152* | 0.1798 | 0.0798 |
1
aOR – adjusted odds ratio. Adjusted for confounders baseline effusion-synovitis, Hoffa-synovitis, body mass index, age, gender, radiographic osteoarthritis severity and malalignment
2
one associated feature: BML or meniscal damage or meniscal extrusion
3
two of three associated features: BML and/or meniscal damage and/or meniscal extrusion)
4
three associated features: BML and/or meniscal damage and/or meniscal extrusion)
*
significant at p < .05
95% CI - 95 % confidence interval