Table 3. Risk of cartilage loss at 30 months for subregions with baseline cartilage score of 0 by grade of prevalent baseline damage severity.
| Cartilage morphology status | Subregions without adjacent pathology TF1 | Subregions with adjacent pathology TF1 | |
|---|---|---|---|
| Reference: Grade 0 and 1 combined: Subregions with cartilage loss at follow-up | 180/7286 (2.47) | 172/2461 (7.0) | |
| aOR3 | 1.0 (reference) | 1.0 (reference) | |
| Grade2.0: Subregions with cartilage loss at FU | 66/ 292 (22.6) | 67/184 (36.4) | |
| aOR3 | 11.3 | 7.74 | |
| 95% CI | (8.06,16.0) | (5.43,11.06) | |
| p | <.0001* | <.0001* | |
| Grade 2.5: Subregions with cartilage loss at FU | 11/103 (10.7) | 23/70 (32.9) | |
| aOR3 | 4.83 | 6.49 | |
| 95% CI | (2.49,9.38) | (3.67,11.48) | |
| p | <.0001* | <.0001* | |
| Grade 3: Subregions with cartilage loss at FU | 106/753 (14.1) | 321/1230 (26.1) | |
| aOR3 | 6.53 | 4.38 | |
| 95% CI | (4.78,9.38) | (3.44,5.57) | |
| p | <.0001* | <.0001* | |
| Grade 4: Subregions with cartilage loss at FU | 1/9 (11.1) | 10/40 (25.0) | |
| aOR3 | 4.94 | 3.43 | |
| 95% CI | (0.80,30.58) | (1.62,7.27) | |
| p | 0.09 | 0.01* | |
| Grades 5 and 6 combined: Subregions with cartilage loss at FU | 11/148 (7.4) | 151/948 (15.9) | |
| aOR3 | 3.27 | 2.18 | |
| 95% CI | (1.60,6.71) | (1.62,2.92) | |
| p | 0.001 | <.0001* | |
*
significant at p <0.05
1
adjacent pathology: meniscal damage and/or meniscal extrusion and/or bone marrow lesion
3
adjusted for age, gender, BMI, malalignment, radiographic OA severity, Hoffa-synovitis, effusion-synovitis
TF- tibio-femoral, PF – patello-femoral, FU – follow-up, aOR – adjusted odds ratio, 95% CI – 95% confidence interval