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. 2013 Dec 16;124(1):285–296. doi: 10.1172/JCI67087

Figure 2. PAX3-FOXO1 regulates a RASSF4 5′ enhancer.

Figure 2

(A) A putative PAX3-FOXO1 binding site 5′ to the RASSF4 gene on human chromosome 10. Figure derived from publically available data in ref. 33. (B) PAX3 and PAX3-FOXO1 directly regulated the RASSF4 5′ enhancer. RD cells were cotransfected with Renilla, a luciferase vector lacking an enhancer, or the RASSF4 5′ enhancer, along with vector, wild-type PAX3, or PAX3-FOXO1. *P < 0.001 compared with vector-expressing cells; #P < 0.005 compared with PAX3-expressing cells.

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