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. 2013 Dec 9;124(1):398–412. doi: 10.1172/JCI71180

Figure 3. A poor outcome tumor subgroup defined by DNA methylation and metabolite profiles.

Figure 3

(A) Heat map representing 2,102 probes highlighting breast tumor subgroups I–III with distinct DNA methylation profiles. Colored bars below the heat map indicate sample classes: red, AA; blue, EA; brown, ER-negative. Percent AA and ER-negative cases in each subgroup is also shown. Box plots above show relative abundance of 2HG in each subgroup (box, interquartile range; line within box, median). Subgroup I is reference for fold difference. (B) Box plots representing relative abundance of SAH and SAM by subgroup. (C) Subgroup III tumors were associated with poor outcome. Kaplan-Meier curves with Cox regression analysis results are shown. HR, hazard ratio. (D) Association between subgroup III DNA methylation signature and breast cancer–specific survival in a publicly available dataset (22). The survival of patients with the subgroup III DNA methylation signature (Subgroup III signature-high) was significantly poorer than that of other patients. Kaplan-Meier curves with Cox regression analysis results are shown.