Fig. 2.

The centrin residues involved in target binding. (A) Graph showing the main human centrin 2 residues interacting with targets XPC and Sfi1. The F113 residue is central to the interaction and makes contacts with the three conserved residues (underlined) that form the hydrophobic triad of the centrin-targets. (B) Sequence alignment of centrins. The three human centrins (HsCen1, HsCen2, HsCen3) are aligned with yeast centrin (Cdc31) and centrin from Scherffelia dubia (SdCen). Amino acids are colored based on their implication in binding to centrin targets. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)