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Phylogeny of mammals used in this study. Species shaded orange can hibernate, and the yellow box indicates the African naked mole-rat. Branches labelled a–g denote functional convergences. The residues in the functional motif (amino acids 1718 to 1720) of NaV1.7 domain IV are shown. ‘+’, ‘–’ and ‘0’ indicate positive, negative and neutral charge of residues, respectively. Residuals on the interior nodes of the tree are the ancestral states of the functional motif.
