Table 1.
susceptibility parameter (symbols explained correspond to the different treatments of figure 1) | treatment |
||||
---|---|---|---|---|---|
naive/challenged (squares) | Ringer/challenged (triangles) | vaccinated/challenged (inverted triangles) | p-value | unchallenged (open circles)¶ | |
LT50 ± s.e.* | 4 ± 0.4a (n = 110) | 5 ± 0.2a (n = 110) | 8 ± 0.5b (n = 110) | overall log rank = 57.5, d.f. = 2 , p ≤ 0.0001† overall Breslow = 41.2, d.f. = 2, p ≤ 0.0001‡ |
>12c (n = 80) |
% survival at 12 days post-challenge | 0 | 0 | 0 | n.a. | 100 |
relative hazard (95%CI) | 4.0 (2.7–5.8)a | 3.0 (2.0–4.3)a | referenceb | overall χ2 = 102.8, d.f. = 6; p ≤ 0.0001 | n.a. |
*LT50 values followed by the same letter denote no significant differences in the pairwise comparisons of survival distributions after a Bonferroni correction.
†Log rank test compared differences in the survival distributions during the earlier parts of the census period.
‡Breslow test compared differences in the survival distributions during the later parts of the census period.
¶The LT50 estimate of unchallenged larvae extended beyond the census period. To generate a conservative analysis, the survival parameters of the unchallenged larvae were not included in the statistical analyses on the fifth column of this table.