Fig. 4.
The pattern of activation for three ROIs that demonstrated significant changes in activation over time with BH4 treatment. The upper and middle panels illustrate regions in left inferior parietal lobule (region 08) and bilateral anterior cingulate cortex (region 13) that showed significant changes between baseline and 4-week evaluation (p < .05 in all instances). The bottom panel illustrates a region in right middle temporal gyrus (region 03) that showed significant changes between baseline and 6-month evaluation. Data is graphed separately for timepoint (baseline, week 4, and 6 month) and BH4 responsiveness (responder vs. non-responder) as determined independently at the 4-week timepoint by each participant's treating physician. For comparison purposes, the mean and standard error of the activation levels observed for the non-PKU group are represented by a dashed line and blue shaded area, respectively.