Table 1.

Regions exhibiting a group (non-PKU and PKU) differences in task-related (2-back minus 0-back) activity.

			Peak activation			Volume	Mean signal change (%)				Effect size
Region	Location	BA	x	y	z	(mm3)	non-PKU	PKU	t value⁎	p value	(d)
PKU > non-PKU
0	Right inferior parietal lobule	40	39	− 61	32	5421	0.01	0.28	3.61	.002	1.54
1	Right fusiform gyrus	19	24	− 74	− 7	1665	− 0.08	0.10	2.83	.010	1.21
2	Bilateral precuneus	7, 31	− 1	− 71	28	3814	− 0.11	0.18	3.58	.002	1.53
3	Right middle temporal gyrus	21	40	2	− 22	733	− 0.09	0.04	3.27	.003	1.39
4	Right inferior parietal lobule	40	53	− 36	25	1888	0.02	0.24	3.04	.006	1.30
5	Right hippocampus	NA	24	− 18	− 9	541	− 0.13	0.05	2.64	.015	1.13
6	Right middle frontal gyrus	8	37	9	30	514	0.11	0.29	2.96	.007	1.26
7	Bilateral superior frontal gyrus	9	5	57	26	616	− 0.41	− 0.13	3.04	.006	1.30
8	Left inferior parietal lobule	7, 19, 40	− 42	− 61	29	973	− 0.11	0.17	2.80	.011	1.19
non-PKU > PKU
9	Left superior frontal gyrus	6	− 23	− 5	57	1194	0.39	0.12	2.82	.010	1.20
10	Left intraparietal sulcus	7, 40	− 25	− 52	35	781	0.25	0.12	3.37	.003	1.44
11	Left middle temporal gryus	21	− 45	0	− 11	893	0.06	− 0.15	3.12	.005	1.33
12	Left middle frontal gyrus	9, 46	− 34	41	25	1621	0.31	0.06	3.17	.004	1.35
13	Bilateral anterior cingulate	32	2	2	46	877	0.25	0.05	2.49	.021	1.06
14	Right precuneous	7	17	− 50	44	514	0.14	0.03	2.73	.012	1.16

Notes. NA: Not applicable. BA: approximate Brodmann's area.

^⁎Degrees of freedom = 22.