FIGURE 4.

EcoHIV-infected interferon-α/β receptor–negative (IFNRKO) mice show greater dysregulation of some inflammatory and immune response genes in the brain versus wild-type (WT) mice. 129/IFNRKO (KO, black bars) and WT mice (gray bars) were infected by intracerebral injection with EcoHIV/NDK or with phosphate-buffered saline (PBS); 4 weeks later, the mice were killed and total cellular RNAs from brain tissues were compared by qPCR for expression of genes known to be involved in human immunodeficiency virus Type 1 (HIV-1) neuropathogenesis in patients. IFNRKO and WT mice inoculated with PBS served as respective controls for measurement of gene expression changes. FC, fold change.