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. 2013 Dec 4;5:ecurrents.eogt.d21e7f0c58463571bb0d9d3a19b82203. [Version 1] doi: 10.1371/currents.eogt.d21e7f0c58463571bb0d9d3a19b82203

Table 2. Studies on the association between the rs4149056 SNP and statin-induced myopathy.

Study Statin type Dose Result
SEARCH
Link 20088 		Simva. 80mg OR 4.5 [CI 2.6-7.7] per C allele

OR 16.9 [CI 4.7-61.1] for
CC homozygotes, P=2x10-9

OR 4.7 [CI 3.5-6.4] P=3x10-28 if HPS controls used as control group
Heart Protection Study
Link 20088 		Simva. 40mg OR 2.6 [CI 1.3-5.0] per C allele, P=0.004
STRENGTH
Voora 200933 		Atorva. 10mg 8 wks, 80mg 8 wks OR 1.6 [CI 0.7-3.7]a
Simva. 20mg 8 wks, 80mg 8 wks OR 2.8 [CI 1.3-6.0]a
Prava. 10mg 8 wks, 40mg 8 wks OR 1.0 [CI 0.4-2.6]a
Brunham 201234 Simva. 10-80mg (mean 30mg) OR 3.2 [CI 0.83-11.96] P=0.042 for CC genotype

OR 2.3 per C allele
Atorva.
10-80mg (mean 30mg)		 OR 1.06 [CI 0.22-4.80], P=0.48
Go-DARTS
Donnelly 201135 		70% simva.
20% atorva.
5% fluva.
5% prava.		 10-160mg OR 2.05 [CI 1.02-4.09], P=0.043 for CC genotype in logistic regression for intolerance.

Highest risk at ≥40mg simvastatin: OR 3.16 [CI 1.40-7.09] P=0.0055 for CC genotype in logistic regression for simvastatin
Puccetti 201042 Atorva. 20-40mg OR 2.7 [CI 1.3-4.9] P<0.001
Rosuva. 20mg OR 0.65 [CI 0.24-1.01] P=0.099
Santos 201243 Atorva. 20-80mg OR 2.24 [CI 0.47-10.72] P=0.31 for myalgia

OR 1.51 [CI 0.57-3.96] P=0.41 for elevated CK
Marciante 201137 Ceriva.
(64% also
on Gem-fibrozil). Controls
on a range of statins		 OR 1.89 [CI 1.40-2.56] P=3.62x10-5 per C allele

OR 4.34 [CI 1.86-10.10] for CC genotype

Stronger association for gemfibrozil users: OR 2.45 [CI 1.61-3.75] P=3.11x10-5 per C allele
JUPITER Danik 201329 Rosuva. 20mg HR 0.95 [CI 0.79-1.15] P=0.59 per C allele for myalgia

HR 0.89 [CI 0.78-1.02] P=0.09 per C allele for muscle weakness,stiffness or pain
Carr 201336 Cases:
78% simva.
14% atorva.
8% other statin
Controls:
60% simva.
30% atorva.
10% other statin		 Cases:
mean dose 33.2mg
Controls:
mean dose 30.6mg		 All statins (n=448)
All myopathy OR 2.08 [CI 1.35-3.23] P=0.005 per C allele;
OR 4.32 [CI 1.82-10.43] for CC vs TT
Severe myopathy OR 4.47 [CI 1.84-10.84] P=0.0003 per C allele;
OR 19.98 [CI 3.38-117.50] for CC vs TT
Simvastatin (n=281)
All myopathy OR 2.13 [CI 1.29-3.54]P=0.014
<40mg OR 1.03 [CI 0.45-2.36] P=0.997
≥40mg OR 3.23 [CI 1.74-5.99] P=0.0002
Severe myopathy OR 4.97 [CI 2.16-11.43] P=0.0004
<40mg OR 1.84 [CI 0.34-9.86] P=0.778
≥40mg OR 6.28 [CI 2.38-16.60] P=0.0004
Atorvastatin (n=121)
All myopathy OR 1.91 [CI 0.56-6.54] P=0.613