Figure 3.

Depressant effects of 5 mmol/L clonidine microinjected into the selected sites of the cNTS on cough reflex responses elicited by mechanical stimulation of the tracheobronchial tree or by the inhalation of 1 mol/L citric acid in one anesthetized spontaneously breathing rabbit. Complete suppression of cough responses 20 min after bilateral microinjections of 5 mmol/L clonidine. Recovery of cough responses was taken ∼2 h after injections. Stimulation periods marked by filled bars. Phr IN, phrenic integrated neurogram; Phr N, phrenic neurogram; Abd IEMG, abdominal integrated electromyographic activity; Abd EMG, abdominal electromyographic activity.