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. 2013 Nov 5;1(6):e00122. doi: 10.1002/phy2.122

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Changes in the cough reflex induced by mechanical stimulation of the tracheobronchial tree or by the inhalation of 1 mol/L citric acid induced by intravenous administration of clonidine in one anesthetized spontaneously breathing rabbit. Reduction and suppression of the cough reflex ∼20 min after the administration of 40 μg/kg and 80 μg/kg clonidine, respectively. In both cases, the complete recovery of cough reflex was obtained ∼15 min after the intravenous administration of yohimbine (300 μg/kg). Stimulation periods marked by filled bars. Phr IN, phrenic integrated neurogram; Phr N, phrenic neurogram; Abd IEMG, abdominal integrated electromyographic activity; Abd EMG, abdominal electromyographic activity.