Table 3.

Cough-related variables before and 15 min after bilateral microinjections of tizanidine into the cVRG (n = 5)

	CN	TT (sec)	TI (sec)	TE (sec)	PPA (RU)	PAA (RU)
Mechanical stimulation
Control	3.8 ± 0.20	0.55 ± 0.03	0.37 ± 0.03	0.18 ± 0.01	0.53 ± 0.04	0.67 ± 0.03
0.5 mmol/L tizanidine	3.6 ± 0.19	0.56 ± 0.03	0.37 ± 0.03	0.19 ± 0.02	0.52 ± 0.04	0.65 ± 0.04
5 mmol/L tizanidine	2.6 ± 0.40*	0.71 ± 0.07*	0.37 ± 0.03	0.34 ± 0.05*	0.52 ± 0.05	0.46 ± 0.08*
Citric acid inhalation
Control	5.8 ± 0.21	0.54 ± 0.03	0.38 ± 0.02	0.17 ± 0.01	0.55 ± 0.06	0.69 ± 0.02
0.5 mmol/L tizanidine	5.2 ± 0.37	0.56 ± 0.04	0.39 ± 0.02	0.18 ± 0.02	0.58 ± 0.06	0.62 ± 0.06
5 mmol/L tizanidine	4.0 ± 0.44*	0.74 ± 0.08*	0.41 ± 0.03	0.33 ± 0.07*	0.59 ± 0.09	0.38 ± 0.06*

Values are means ± SEM; n, number of animals; CN, cough number; T_T, cycle duration; T_I, inspiratory time; T_E, expiratory time; PPA, peak phrenic activity in relative units (RU); PAA, peak abdominal activity in relative units (RU).

^*P < 0.05 compared with control cough and 0.5 mmol/L tizanidine.