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. 2013 Nov 11;1(6):e00130. doi: 10.1002/phy2.130

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Fetal intravenous cortisol infusion increased glucocorticoid activating enzyme mRNA expression in the fetal lung. Normalized mRNA expression of 11β hydroxysteroid dehydrogenase isoform 1 (HSD11B-1, A) was increased with age and cortisol infusion. There was no change in normalized mRNA expression of the glucocorticoid deactivating enzyme (HSD11B-2, B), glucocorticoid receptor (NR3C1, C) or the mineralocorticoid receptor (NR3C2, D) with age or cortisol infusion. Data expressed as mean ± SEM. P < 0.05 was considered statistically significant; columns with different letters are significantly different from each other. 116-day saline-infused, open bars; 116-day cortisol-infused, black bars; 140-day saline-infused, gray bars.