Table 1.
Renal clearance and hemodynamic parameters
| Baseline | Clearance period 1 | Clearance period 2 | |
|---|---|---|---|
| A1 | |||
| V (μL/min) | 10.54 ± 2.21 | 43.91 ± 6.31* | 38.63 ± 5.55* |
| UNaV (μEq/min) | 1.15 ± 0.4 | 3.21 ± 1.12* | 3.99 ± 0.95* |
| FENa (%) | 0.37 ± 0.12 | 0.96 ± 0.38 | 1.63 ± 0.46* |
| UKV (μEq/min) | 1.34 ± 0.21 | 2.72 ± 0.19* | 2.82 ± 0.19* |
| FEK (%) | 14.32 ± 2.1 | 22.59 ± 1.6 | 34.2 ± 2.78* |
| GFR (mL/min) | 1.94 ± 0.19 | 2.67 ± 0.24 | 1.94 ± 0.16 |
| MAP (mmHg) | 120.1 ± 2.25 | 112.9 ± 3.31* | 108.2 ± 3.85* |
| B2 | |||
| V (μL/min) | 6.44 ± 1.16 | 13.9 ± 1.78* | 7.68 ± 1.6 |
| UNaV (μEq/min) | 0.67 ± 0.36 | 1.68 ± 0.53 | 1.55 ± 0.38 |
| FENa (%) | 0.34 ± 0.19 | 0.49 ± 0.25 | 0.6 ± 0.26 |
| UKV (μEq/min) | 1.16 ± 0.32 | 1.49 ± 0.25 | 1.26 ± 0.26 |
| FEK (%) | 14.53 ± 3.9 | 17.76 ± 4.0 | 23.95 ± 5.0* |
| GFR (mL/min) | 1.53 ± 0.09 | 2 ± 0.24 | 1.39 ± 0.22 |
| MAP (mmHg) | 118.7 ± 6.95 | 109.2 ± 6.84 | 98.2 ± 5.39* |
Data represent the means ± SEM. V, urine flow rate; UNaV, absolute rate of sodium excretion; GFR, glomerular filtration rate; FENa, fractional excretion of sodium; FEK, fractional excretion of potassium.
*
denotes P < 0.05.
1
Effects of two incremental doses of XAG on renal clearance parameters in normal rats (n = 8).
2
Time control group infused with equivalent volumes of saline instead of the compound (n = 5).