Table 2.
Clearance parameters in amiloride pretreated rats
| Baseline | Clearance period 1 | Clearance period 2 | ||||
|---|---|---|---|---|---|---|
| −XAG | +XAG | −XAG | +XAG | −XAG | −XAG | |
| V (μL/min) | 18.64 ± 3.23 | 17.17 ± 0.99 | 33.46 ± 5.652 | 30.24 ± 2.782 | 35.03 ± 3.822 | 24.67 ± 3.96 |
| UNaV (μEq/min) | 2.67 ± 0.49 | 3.02 ± 0.48 | 4.82 ± 0.922 | 3.94 ± 0.29 | 5.29 ± 0.652 | 3.07 ± 0.331 |
| UKV (μEq/min) | 0.03 ± 0.01 | 0.04 ± 0.01 | 0.1 ± 0.032 | 0.08 ± 0.022 | 0.11 ± 0.032 | 0.09 ± 0.022 |
| FENa (%) | 1.78 ± 0.18 | 1.23 ± 0.12 | 2.44 ± 0.44 | 1.83 ± 0.192 | 2.5 ± 0.41 | 1.81 ± 0.192 |
| FEK (%) | 0.6 ± 0.15 | 0.62 ± 0.17 | 1.38 ± 0.54 | 1.51 ± 0.622 | 1.49 ± 0.552 | 1.86 ± 0.612 |
| GFR (mL/min) | 1.18 ± 0.17 | 1.66 ± 0.21 | 1.58 ± 0.24 | 1.62 ± 0.17 | 1.86 ± 0.312 | 1.32 ± 0.19 |
| MAP (mmHg) | 115 ± 4.4 | 117.3 ± 3.3 | 111.2 ± 3.1 | 109.6 ± 3.92 | 109.9 ± 2.6 | 103.5 ± 3.32 |
Effect of amiloride pretreatment on the effects of two incremental doses of XAG on renal clearance parameters in normal rats. Data represent the means ± SEM. V, urine flow rate; UNaV, absolute rate of sodium excretion; GFR, glomerular filtration rate; FENa, fractional excretion of sodium; FEK, fractional excretion of potassium; UKV, rate of urinary potassium excretion.
1
Statistical significance in −XAG vs. +XAG groups.
2
Statistical significance in Clearance period 1, Clearance period 2 vs. baseline.