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. 2013 Nov 19;1(6):e00160. doi: 10.1002/phy2.160

Figure 4.

Figure 4

Effect of S219R and L220F mutations on ROMK channel activity. Relative outward potassium currents recorded by two-electrode voltage -clamp in Xenopus oocytes expressing ROMK. Oocytes were injected with 250 pg cRNA-encoding wild type (WT), S219R, or L220F mutant channel subunits. To mimic the compound heterozygous state of the patients, oocytes were coinjected with mixtures (given in parentheses) of the different cRNAs (250 pg in total). Data are mean ± SEM (n = 18 oocytes/group, from three frogs). ***P < 0.001; **P < 0.01; ns, P > 0.05 versus WT potassium current. #P < 0.001 versus WT+S219R current.