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. 2013 Nov 19;1(6):e00163. doi: 10.1002/phy2.163

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Reduction in contrast-induced inhibition of renal tubule epithelial cell proliferation by PACAP. (A) Incubation of HK-2 cells with iohexol caused a large decrease in the rate of proliferation. PACAP38 and VIP attenuated the decreased in the rate of proliferation in a dose-dependent manner. PACAP38 was more potent than VIP. (B) Incubation of HK-2 cells with Urografin caused a very large decrease in the rate of proliferation. PACAP38 attenuated the decreased in the rate of proliferation in a dose-dependent manner. *P < 0.05 and **P < 0.01 compared to the cells treated only with the same contrast medium. ^†P < 0.05 and ^††P < 0.01 compared to the cells treated with the same dose of VIP. Bars represent the mean ± SD. PACAP, pituitary adenylate cyclase-activating polypeptide; VIP, vasoactive intestinal peptide; HK-2, human kidney-2.