. 2013 Dec 7;2013:853602. doi: 10.1155/2013/853602

Table 2.

Pharmacokinetic parameters of INH in plasma among fast, intermediate, and slow acetylators by the chromatographic method.

Genotype of acetylation	Pharmacokinetic parameters of INH
Genotype of acetylation	I ₃	C ₆	K _e	T _0,5	C _max	AUC_0–6	AUC_total
Fast	0,36^a	0,27^a	0,51^b	1,59^a	3,39^a	8,6^a	9,2^a
Intermediate	0,55^a	0,70^a	0,41^b	1,85^a	5,80^b	15,4^b	17,5^b
Slow	0,97^b	2,20^b	0,27^a	3,14^b	7,09^c	24,5^c	35,5^c

The different letters in the columns indicate significant differences (at P ≤ 0.05) between the respective types of acetylation.

I ₃: index of acetylation.

C ₆: concentration of INH 6 hours after drug administration.

K _e: fixed speed of elimination 1/h.

T _0,5: elimination half time.

AUC_0–6: area under concentration curve in the period 0–6 hours.

AUC_total: area under concentration curve.