Table 1.
Characteristics of Participants and Nonparticipants
| Characteristic | Participants (n = 1,922) |
Nonparticipants (n = 1,031) |
Comparison Group (n = 341) |
|||
|---|---|---|---|---|---|---|
| No. of Patients | % | No. of Patients | % | No. of Patients | % | |
| Sex | ||||||
| Female | 956 | 49.7 | 425 | 41.2* | 166 | 48.7 |
| Male | 966 | 50.3 | 606 | 58.8 | 175 | 51.3 |
| Age at assessment, years | ||||||
| 18-29 | 707 | 36.8 | 277 | 26.9* | 201 | 58.9* |
| 30-39 | 797 | 41.4 | 435 | 42.2 | 117 | 34.3 |
| 40-60.6† | 418 | 21.8 | 319 | 30.9 | 23 | 6.7 |
| Age at diagnosis, years | ||||||
| 0-4 | 747 | 38.9 | 377 | 36.6 | ||
| 5-9 | 463 | 24.1 | 261 | 25.3 | ||
| 10-14 | 414 | 21.5 | 226 | 21.9 | ||
| 15-28.6 | 298 | 15.5 | 167 | 16.2 | ||
| Time since diagnosis, years | ||||||
| 10-19 | 509 | 26.5 | 193 | 18.7* | ||
| 20-29 | 873 | 45.4 | 445 | 43.2 | ||
| 30-48.9 | 540 | 28.1 | 393 | 38.1 | ||
| Diagnosis | ||||||
| Leukemia | 841 | 43.8 | 395 | 38.3‡ | ||
| CNS tumor | 148 | 7.7 | 85 | 8.3 | ||
| Hodgkin's lymphoma | 253 | 13.2 | 120 | 11.6 | ||
| Non-Hodgkin's lymphoma | 110 | 5.7 | 91 | 8.8 | ||
| Neuroblastoma | 78 | 4.0 | 53 | 5.2 | ||
| Wilms tumor | 120 | 6.2 | 62 | 6.0 | ||
| Soft tissue sarcoma | 94 | 4.9 | 64 | 6.2 | ||
| Bone tumor | 136 | 7.1 | 72 | 7.0 | ||
| Retinoblastoma | 67 | 3.5 | 32 | 3.1 | ||
| Other solid tumor | 75 | 3.9 | 57 | 5.5 | ||
| Radiation | ||||||
| Chest | 580 | 30.2 | 293 | 28.4 | ||
| Abdomen/pelvis | 497 | 25.9 | 247 | 24.0 | ||
| Cranial | 674 | 35.1 | 315 | 30.6* | ||
| Other radiation | 123 | 6.4 | 73 | 7.1 | ||
| Chemotherapy | ||||||
| Any chemotherapy | 1,677 | 87.3 | 850 | 82.4* | ||
| Anthracyclines | 1,116 | 58.1 | 554 | 53.7§ | ||
| Alkylating agents | 1,184 | 61.6 | 594 | 57.6§ | ||
| Glucocorticoids | 1,009 | 54.0 | 478 | 46.4‡ | ||
| Platinum | 180 | 9.4 | 107 | 10.4 | ||
| Vinca-alkaloids | 1,480 | 77.0 | 722 | 70.0* | ||
| Methotrexate, IV/IT§ | 1,024 | 53.3 | 507 | 49.2§ | ||
| Surgery | ||||||
| Brain | 198 | 10.3 | 88 | 8.5 | ||
| Thoracotomy | 178 | 9.3 | 70 | 6.8§ | ||
| Laparotomy | 577 | 30.0 | 280 | 27.2 | ||
| Amputation | 60 | 3.1 | 25 | 2.4 | ||
| Limb sparing | 78 | 4.1 | 25 | 2.4§ | ||
| Body mass index, kg/m2¶ | ||||||
| < 18.5 | 68 | 3.5 | 9 | 2.6 | ||
| 18.5-24.9 | 604 | 31.4 | 135 | 40.0‡ | ||
| 25-29.9 | 552 | 29.0 | 93 | 27.2 | ||
| 30-39.9 | 539 | 28.1 | 83 | 24.3 | ||
| ≥ 40 | 155 | 8.1 | 21 | 6.2 | ||
| Smoking status | ||||||
| Never smoked | 1,240 | 64.5 | 209 | 61.3 | ||
| Former smoker | 230 | 12.0 | 36 | 10.6 | ||
| Current smoker | 435 | 22.6 | 96 | 28.2§ | ||
| Not reported | 17 | 0.9 | 0 | 0.0 | ||
| Heavy drinkers‖ | 66 | 3.5 | 19 | 5.6 | ||
Abbreviation: IV/IT, intravenous or intrathecal.
*
P < .001 (all comparisons are with survivor participants).
†
Of the patients who were 50-59 years old, 32 were men and 29 were women; one woman was 60 years old.
‡
P < .01 (all comparisons are with survivor participants).
§
P < .05 (all comparisons are with survivor participants).
¶
Adjusted for amputation.
‖
Men: five or more drinks per day or 14 drinks per week; women: four or more drinks per day or seven drinks per week.