Table 2.
Univariate and Multivariate Analysis (Cox model) of Overall Survival
| Parameter | Univariate |
Multivariate (n = 433) |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Post-ASCT response | ||||||
| sCR v CR | 0.37 | 0.21 to 0.67 | .001 | 0.44 | 0.25 to 0.80 | .008 |
| sCR v nCR | 0.30 | 0.18 to 0.46 | < .001 | 0.35 | 0.22 to 0.56 | < .001 |
| sCR v VGPR* | 0.35 | 0.21 to 0.58 | < .001 | 0.42 | 0.25 to 0.70 | < .001 |
| sCR v PR | 0.34 | 0.21 to 0.53 | < .001 | 0.45 | 0.28 to 0.74 | .001 |
| sCR v SD | 0.30 | 0.16 to 0.60 | .001 | 0.33 | 0.16 to 0.67 | .003 |
| sCR v PD | 0.09 | 0.05 to 0.18 | < .001 | 0.14 | 0.06 to 0.28 | < .001 |
| Plasma cell labeling index, % | 5.02 | 3.29 to 7.36 | < .001 | 3.9 | 2.4 to 6.0 | < .001 |
| ≥ 3 v < 3 | ||||||
| β2-microglobulin, μg/mL | 1.5 | 1.09 to 1.95 | .01 | 1.08 | 0.78 to 149 | .63 |
| ≥ 3.5 v < 3.5 | ||||||
| Lactate dehydrogenase, u/L | 0.75 | 0.57 to 1.01 | .06 | |||
| Normal v abnormal | ||||||
| ECOG PS | ||||||
| > 1 v 0, 1 | 1.90 | 1.26 to 2.76 | .003 | 1.7 | 1.1 to 2.5 | .02 |
| Cytogenetics | ||||||
| Normal v abnormal | 0.48 | 0.35 to 0.67 | < .001 | 0.67 | 0.47 to 0.97 | .03 |
| Pre-ASCT response | 0.81 | 0.58 to 1.13 | .2 | |||
| PR v < PR | 0.57 | 0.44 to 0.74 | < .001 | |||
| Age, years | 0.99 | 0.73 to 1.33 | .95 | |||
| ≥ 65 v < 65 | ||||||
| Creatinine, mg/dL | 1.03 | 0.58 to 1.67 | .92 | |||
| ≥ 2 v 2 | ||||||
Abbreviations: ASCT, autologous stem-cell transplantation; CR, complete response; ECOG PS, Eastern Cooperative Oncology Group performance status; HR, hazard ratio; nCR, near complete response; PD, progressive disease; PR, partial response; sCR, stringent complete response; SD, stable disease; VGPR, very good partial response.
*
Excluding nCR.