Table 4.
Relationship Between Pro-SFTPB and the Risk of NSCLC in the CARET Study According to Quintiles of Serum Pro-SFTPB Concentrations
| Variable | Q1 |
Q2 |
Q3 |
Q4 |
Q5 |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | OR* | Adjusted OR† | No. | OR* | 95% CI | Adjusted OR† | 95% CI | No. | OR* | 95% CI | Adjusted OR† | 95% CI | No. | OR* | 95% CI | Adjusted OR† | 95% CI | No. | OR* | 95% CI | Adjusted OR† | 95% CI | |
| Total | 26 | 1 (ref) | 1 (ref) | 29 | 2.64 | 0.46 to 15.11 | 2.74 | 0.42 to 17.12 | 35 | 5.61 | 1.11 to 28.37 | 6.66 | 1.15 to 38.32 | 45 | 11.63 | 2.40 to 56.33 | 12.24 | 2.22 to 67.43 | 46 | 12.34 | 2.54 to 60.00 | 9.64 | 1.74 to 53.34 |
| Controls‡ | 24 | 24 | 24 | 24 | 24 | ||||||||||||||||||
| NSCLC | 2 | 5 | 11 | 21 | 22 | ||||||||||||||||||
Abbreviations: BMI, body mass index; CARET, Carotene and Retinol Efficacy Trial; NSCLC, non–small-cell lung cancer; OR, odds ratio; pro-SFTPB, pro–surfactant protein B; Q, quartile.
*
Adjusted for matching variables (age, sex, smoking status, enrollment period, and blood draw visit). Ptrend < .001.
†
Adjusted for matching variables (pack-years, years since quitting smoking, asbestos exposure, and BMI). Ptrend = .001.
‡
One sample was excluded from this analysis because of missing BMI data.