Table 3.

Proteins interacting with Sox2 and the roles of complex

Interacted proteins	Roles of Complex	References
Oct-3	Synergistically activates the enhancer of FGF4	[45]
Oct-3	Generates a functional complex and activates FGF4 enhancer	[46]
HDAC1 HDAC2 Sall4 Lin28	HDAC1-Sox2 complex contributes to transcriptional repression of a subset of genes such as Sox21	[42] [44]
Chd7	Regulates many genes expression including Jag1, Gli3 and Mycn which could lead to Alagille, Pallister-Hall and Feingold syndromes	[39] [47]
CD44v3, Oct-4, Nanog	Promotes microRNA-302 expression and self-renewal, clonal formation and cisplatin resistance in CSCs	[25]
β-catenin	Modulates the expression of Cyclin D1	[43]