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. 2013 Dec 23;8(12):e82847. doi: 10.1371/journal.pone.0082847

Table 1. The top 10 genes that were differentially regulated in the HFD and Sal mouse groups.

Upregulated in HFD mice relative to NC mice
Genes NC HFD Sal
Matrix metallopeptidase 12 (Mmp12) 1.00±0.10 285.41±3.65 290.41±4.66
Ring finger protein 128 (Rnf128) 1.00±0.14 54.84±3.88 47.33±0.52
Glycoprotein (transmembrane) nmb (Gpnmb) 1.00±0.11 27.90±2.54 34.98±1.38
Interleukin 7 receptor (Il7r) 1.00±0.04 26.89±0.74 46.29±0.97
Glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (Qpct) 1.00±0.29 26.43±1.09 24.24±2.09
Lipoprotein lipase (Lpl) 1.00±0.04 24.77±0.50 27.07±0.23
V-set and immunoglobulin domain containing 8 (Vsig8) 1.00±0.07 24.16±1.25 28.75±0.25
Fibroblast growth factor 13 (Fgf13) 1.00±0.29 20.66±0.77 12.73±0.46
Coagulation factor VII (F7) 1.00±0.10 20.29±1.21 41.00±0.24
Cathepsin K, (Ctsk) 1.00±0.04 20.17±0.30 19.93±0.93
Upregulated in Sal mice relative to NC mice
Genes NC HFD Sal
Matrix metallopeptidase 12 (Mmp12) 1.00±0.10 285.41±3.65 290.41±4.66
Ring finger protein 128 (Rnf128) 1.00±0.14 54.84±3.88 47.33±0.52
Interleukin 7 receptor (Il7r) 1.00±0.04 26.89±0.74 46.29±0.97
Coagulation factor VII (F7) 1.00±0.10 20.29±1.21 41.00±0.24
Glycoprotein (transmembrane) nmb (Gpnmb) 1.00±0.11 27.90±2.54 34.98±1.38
V-set and immunoglobulin domain containing 8 (Vsig8) 1.00±0.07 24.16±1.25 28.75±0.25
Lipoprotein lipase (Lpl) 1.00±0.04 24.77±0.50 27.07±0.23
Glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (Qpct) 1.00±0.29 26.43±1.09 24.24±2.09
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (Kcnn4) 1.00±0.03 16.11±0.50 22.18±0.30
Protocadherin 7 (Pcdh7) 1.00±0.07 18.41±2.66 21.32±1.68
Upregulated in Sal mice relative to HFD mice
Genes NC HFD Sal
immunoglobulin lambda chain, constant region 3 (Igl-C3) 1.16±0.05 1.00±0.04 6.45±0.49
Dedicator of cytokinesis 7 (Dock7) 0.82±0.29 1.00±0.29 4.23±0.56
Kinesin family member 13B (Kif13b) 0.86±0.05 1.00±0.02 4.16±0.36
Immunoglobulin lambda chain, constant region 2 (Igl-C2) 0.15±0.04 1.00±0.04 3.38±0.11
NFκB inhibitorξ (Nfkbiz) 0.96±0.01 1.00±0.09 3.04±0.03
Forkhead box P1 (Foxp1) 1.83±0.23 1.00±0.02 2.99±0.26
Eosinophil-associated, ribonuclease A family (Ear) 0.34±0.00 1.00±0.00 2.97±0.13
Lactate dehydrogenase C (Ldhc) 0.96±0.00 1.00±0.05 2.94±0.37
Acyl-Coenzyme A binding domain containing 3 (Acbd3) 1.50±0.04 1.00±0.03 2.90±0.14
Cut-like homeobox 1 (Cux1) 2.02±0.00 1.00±0.05 2.90±0.20
Downregulated in HFD mice relative to NC mice
Genes NC HFD Sal
Aldo-keto reductase family 1, member B7 (Akr1b7) 1.00±0.12 0.02±0.00 0.01±0.00
Protamine 1 (Prm1) 1.00±0.06 0.02±0.00 0.02±0.00
Dysteine-rich secretory protein 1 (Crisp1) 1.00±0.02 0.03±0.00 0.02±0.00
Clusterin (Clu) 1.00±0.06 0.03±0.00 0.04±0.00
Carboxylesterase 3 (Ces3) 1.00±0.06 0.03±0.00 0.04±0.00
Complement factor D (adipsin) (Cfd) 1.00±0.08 0.04±0.00 0.04±0.00
Uroplakin 3B (Upk3b) 1.00±0.07 0.04±0.00 0.07±0.00
Uroplakin 1B (Upk1b) 1.00±0.07 0.05±0.00 0.05±0.00
Keratin 8 (Krt8) 1.00±0.20 0.05±0.00 0.06±0.00
Carbonic anhydrase 3 (Car3) 1.00±0.03 0.06±0.00 0.40±0.00
Downregulated in Sal mice relative to NC mice
Genes NC HFD Sal
Aldo-keto reductase family 1, member B7 (Akr1b7) 1.00±0.12 0.02±0.00 0.01±0.00
Cysteine-rich secretory protein 1 (Crisp1) 1.00±0.02 0.03±0.00 0.02±0.00
Selectin, platelet (Selp) 1.00±0.03 0.10±0.01 0.02±0.00
Protamine 1 (Prm1) 1.00±0.06 0.02±0.00 0.02±0.00
Serum amyloid A 3 (Saa3) 1.00±0.01 0.17±0.00 0.04±0.00
Complement factor D (adipsin) (Cfd) 1.00±0.08 0.04±0.00 0.04±0.00
Clusterin (Clu) 1.00±0.06 0.03±0.00 0.04±0.00
Carboxylesterase 3 (Ces3) 1.00±0.06 0.03±0.00 0.04±0.00
Uroplakin 1B (Upk1b) 1.00±0.07 0.05±0.00 0.05±0.00
Histidine decarboxylase, (Hdc) 1.00±0.02 0.16±0.00 0.05±0.00
Downregulated in Sal mice relative to HFD mice
Genes NC HFD Sal
Igκ chain variable 28 (Igk-V28) 0.16±0.01 1.00±0.06 0.12±0.01
Nudix (nucleoside diphosphate linked moiety X)-type motif 21 (Nudt21) 0.16±0.15 1.00±0.01 0.13±0.01
Fascin homolog 1, actin bundling protein (Fscn1) 0.88±0.02 1.00±0.07 0.18±0.03
Cytoplasmic polyadenylation element binding protein 2, Cpeb2 1.34±0.21 1.00±0.06 0.19±0.01
CD5 antigen-like (Cd5l) 0.51±0.02 1.00±0.04 0.20±0.02
GC-rich promoter binding protein 1 (Gpbp1) 1.68±0.29 1.00±0.06 0.20±0.05
Serum amyloid A 3 (Saa3) 5.84±0.03 1.00±0.00 0.21±0.01
Nudix (nucleoside diphosphate linked moiety X)-type motif 21 (Nudt21) 0.60±0.07 1.00±0.11 0.22±0.00
Selectin, platelet (Selp) 10.06±0.27 1.00±0.08 0.23±0.02
Selenoprotein W, muscle 1 (Sepw1) 3.07±0.47 1.00±0.02 0.25±0.00