Table 3. Comparison of biosynthetic metabolites in EtOH or ACR-treated JHH7 and Hc cells determined by CE-TOFMS.

Biosynthetic pathways	Metabolites	KEGG	Fold change
			EtOH-treated JHH7 vs. Hc		ACR vs. EtOH-treated JHH7
			Mean	SEM	Mean	SEM
Nucleotide biosynthesis	AMP	C00020	2.50	0.10	0.82	0.00
	ATP	C00002	1.64	0.02	0.72	0.01
	CTP	C00063	1.84	0.11	0.74	0.05
	dATP	C00131	1.26	0.02	0.47	0.07
	dCTP	C00458	2.74	0.06	0.69	0.07
	dTTP	C00459	1.96	0.04	0.61	0.06
	GDP	C00035	2.76	0.15	0.82	0.02
	GTP	C00044	1.67	0.11	0.74	0.04
	IMP	C00130	2.33	0.11	0.71	0.08
	PRPP	C00119	0.68	0.08	0.53	0.11
	Ribulose 5-P	C00199	0.46	0.05	0.68	0.05
	UDP	C00015	2.81	0.05	0.82	0.05
	UTP	C00075	1.22	0.04	0.68	0.02
Amino acid biosynthesis	Ala	C00041	9.23	0.31	0.79	0.02
	Asp	C00049	3.23	0.08	0.77	0.01
	Glu	C00025	1.38	0.02	0.76	0.01
	Gly	C00037	0.64	0.02	0.82	0.01
	Ile	C00407	0.80	0.03	0.79	0.01
	Leu	C00123	0.73	0.03	0.78	0.02
	Lys	C00047	1.94	0.06	0.77	0.03
	Phe	C00079	0.69	0.02	0.78	0.01
	Ser	C00065	5.31	0.20	0.81	0.02
	Thr	C00188	1.94	0.07	0.77	0.00
	Trp	C00078	0.06	0.00	0.78	0.02
	Tyr	C00082	0.71	0.03	0.79	0.02
	Val	C00183	0.83	0.04	0.78	0.02
Lipid biosynthesis	3-Hydroxybutyric acid	C01089	1.58	0.03	0.82	0.03
	DHAP	C00111	0.28	0.03	0.52	0.03