Skip to main content
. 2013 Dec 23;8(12):e83247. doi: 10.1371/journal.pone.0083247

Figure 7. Ultrathin sections of L. amazonensis promastigotes treated with different concentrations of ITZ and POSA.

Figure 7

(A, B) 1 µM ITZ; (C, D) 1 µM POSA; (E) 3 µM POSA for 48 h; (F) 5 µM POSA for 72 h. Several alterations were observed in the mitochondrion-kinetoplast complex such as: intense disorganization and swelling (A, B, D); alterations in the mitochondrion membranes and the appearance of circular cristae (B, C, arrows); changes in the structure of the kinetoplast (B, D, E, F); and the presence of autophagosomes (A, C, D). In Fig. 7E, two large vacuoles containing membranes and portions of the cytoplasm were observed (asterisks). FP, flagellar pocket; GC, Golgi complex; k: kinetoplast; m, mitochondrion; N: nucleus, A: autophagosome.